The public policy of the Islamic Republic of Iran in the field of foreign policy, especially in the West Asian region, has always been influenced by geopolitical, security, and ideological considerations. One of the most important areas of this policymaking is the developments in Syria and its position in regional equations. The Syrian crisis and the collapse of Bashar al-Assad’s government have had far-reaching consequences for Iran’s security and regional influence, and the reaction of Western countries has also added to the complexity of these conditions. This article, focusing on the “balance of interests” approach, examines Iran’s strategies in dealing with these developments. The research findings show that Iran, by utilizing tools such as soft balancing, regional coalition building and support for proxy forces, multi-level and multilateral diplomacy, limited military measures aimed at deterrence, media diplomacy and rational representation in global public opinion, has tried to maintain its position in the axis of resistance and regional equations while reducing security threats from Western powers. Iran's approach focuses on the use of low-cost and flexible tools rather than relying on hardware balancing and direct military spending. Accordingly, Iran's foreign policy towards Western countries in the process of developments in Syria has been redefined based on maintaining national security and consolidating regional influence through multi-faceted and low-cost strategies.